What's Up With Human Chromosome 2 On A Most Real Level

 



  • Chimpanzees have more chromosomes than we do: a total of 48.
    • One could say we are missing 2 chromosomes given we have 2 less at 46.
    • Where did they go?
  • Gregg is saying - It's not actually missing. That it's been modified and arranged in a way that wasn't obvious in the past as we didn't have the DNA sequencing technology to see it.
  • Human Chromosome 2 (HC2)
    • The second largest chromosome in the human body - forms 8% of the DNA in cells is HC2 - This contains the smaller "missing" chromosome found in the chimpanzee genome.
      • This points to the hypothesis that two separate chimpanzee chromosomes were combined into a single longer chromosome, that is what we call HC2. 
      • FOXP2 - It is acknowledged that mutations have occurred in FOXP2.
  • How did the 2 combine into 1?
    • Science Explanation: "We conclude that the locus cloned in cosmids c8.1 and c29B is the relic of an ancient telomere-telomore fusion and marks the point at which two ancestral ape chromosomes fused to give rise to human chromosome 2.
    • Regular Person Explanation: It appears that long ago two separate chromosomes from chimpanzees (2A and 2B) merged or fused into the single, larger human chromosome 2 - which is one of the key chromosomes that give us our humanness.
  • What are HC2 Traits:








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